U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Medullary breast carcinoma

MedGen UID:
163568
Concept ID:
C0860580
Neoplastic Process
Synonyms: Breast Medullary Carcinoma; breast medullary carcinoma; Infiltrating Medullary Carcinoma of Breast; infiltrating medullary carcinoma of breast; Infiltrating Medullary Carcinoma of the Breast; infiltrating medullary carcinoma of the breast; Invasive Medullary Breast Carcinoma; invasive medullary breast carcinoma; Invasive Medullary Carcinoma of Breast; invasive medullary carcinoma of breast; Invasive Medullary Carcinoma of the Breast; invasive medullary carcinoma of the breast; medullary breast cancer; Medullary Breast Carcinoma; medullary breast carcinoma; Medullary Breast Carcinoma with Lymphoid Stroma; medullary breast carcinoma with lymphoid Stroma; Medullary Carcinoma of Breast; medullary carcinoma of breast; Medullary Carcinoma of the Breast; medullary carcinoma of the breast
 
Monarch Initiative: MONDO:0005063

Definition

An infiltrating breast carcinoma with a relatively favorable prognosis. It is an uncommon carcinoma, accounting for less than 1% of all infiltrating breast carcinomas. It is well circumscribed, with soft cut surface and often of considerable size. Microscopically, the predominant growth pattern is syncytial with broad anastomosing bands or sheets of malignant cells. The malignant cells are round with abundant cytoplasm and vesicular nuclei. The sheets of malignant cells are associated with a marked lymphoplasmacytic infiltrate. Glandular or tubular structures are absent. [from NCI]

Professional guidelines

PubMed

Spitzer E, Abbaszadegan MR, Schmidt F, Hauser A, Buwitt U, Lauter FR, Pötschick K, Krocker J, Elling D, Grosse R
Int J Cancer 2000 Feb 15;85(4):474-81. doi: 10.1002/(sici)1097-0215(20000215)85:4<474::aid-ijc5>3.0.co;2-4. PMID: 10699917
Fourquet A, Vilcoq JR, Zafrani B, Schlienger P, Jullien D, Campana F
Radiother Oncol 1987 Sep;10(1):1-6. doi: 10.1016/s0167-8140(87)80063-4. PMID: 3671767

Recent clinical studies

Etiology

Aihara T, Kumamaru H, Ishitobi M, Miyashita M, Miyata H, Tamura K, Yoshida M, Ogo E, Nagahashi M, Asaga S, Kojima Y, Kadoya T, Aogi K, Niikura N, Iijima K, Hayashi N, Kubo M, Yamamoto Y, Takeuchi Y, Imoto S, Jinno H
Breast Cancer Res Treat 2022 Dec;196(3):635-645. Epub 2022 Oct 23 doi: 10.1007/s10549-022-06749-3. PMID: 36273358
Lee M, Jara-Lazaro AR, Cheok PY, Thike AA
Singapore Med J 2022 Jul;63(7):394-401. Epub 2021 Apr 16 doi: 10.11622/smedj.2021031. PMID: 33866710Free PMC Article
Romero P, Benhamo V, Deniziaut G, Fuhrmann L, Berger F, Manié E, Bhalshankar J, Vacher S, Laurent C, Marangoni E, Gruel N, MacGrogan G, Rouzier R, Delattre O, Popova T, Reyal F, Stern MH, Stoppa-Lyonnet D, Marchiò C, Bièche I, Vincent-Salomon A
Am J Pathol 2018 Oct;188(10):2378-2391. Epub 2018 Aug 1 doi: 10.1016/j.ajpath.2018.06.021. PMID: 30075151
Chu Z, Lin H, Liang X, Huang R, Tang J, Bao Y, Jiang J, Zhan Q, Zhou X
Jpn J Clin Oncol 2015 Jul;45(7):637-41. Epub 2015 Apr 10 doi: 10.1093/jjco/hyv052. PMID: 25862826
Chu Z, Lin H, Liang X, Huang R, Zhan Q, Jiang J, Zhou X
PLoS One 2014;9(11):e111493. Epub 2014 Nov 6 doi: 10.1371/journal.pone.0111493. PMID: 25375803Free PMC Article

Diagnosis

Lee M, Jara-Lazaro AR, Cheok PY, Thike AA
Singapore Med J 2022 Jul;63(7):394-401. Epub 2021 Apr 16 doi: 10.11622/smedj.2021031. PMID: 33866710Free PMC Article
Chu Z, Lin H, Liang X, Huang R, Tang J, Bao Y, Jiang J, Zhan Q, Zhou X
Jpn J Clin Oncol 2015 Jul;45(7):637-41. Epub 2015 Apr 10 doi: 10.1093/jjco/hyv052. PMID: 25862826
Chu Z, Lin H, Liang X, Huang R, Zhan Q, Jiang J, Zhou X
PLoS One 2014;9(11):e111493. Epub 2014 Nov 6 doi: 10.1371/journal.pone.0111493. PMID: 25375803Free PMC Article
Cao AY, He M, Huang L, Shao ZM, Di GH
World J Surg Oncol 2013 Apr 22;11:91. doi: 10.1186/1477-7819-11-91. PMID: 23607710Free PMC Article
Malyuchik SS, Kiyamova RG
Exp Oncol 2008 Jun;30(2):96-101. PMID: 18566570

Therapy

Chen H, Pu S, Wang L, Zhang H, Yan Y, He J, Zhang J
Sci Rep 2023 Jul 3;13(1):10704. doi: 10.1038/s41598-023-37915-2. PMID: 37400489Free PMC Article
Sharma P, Jain S, Nigam S, Bahadur AK, Ouseph MM
Acta Cytol 2006 Sep-Oct;50(5):577-80. doi: 10.1159/000326020. PMID: 17017451
Kotlan B, Simsa P, Teillaud JL, Fridman WH, Toth J, McKnight M, Glassy MC
J Immunol 2005 Aug 15;175(4):2278-85. doi: 10.4049/jimmunol.175.4.2278. PMID: 16081796
Simsa P, Teillaud JL, Stott DI, Tóth J, Kotlan B
Pathol Oncol Res 2005;11(2):92-7. Epub 2005 Jul 1 doi: 10.1007/BF02893374. PMID: 15999153

Prognosis

Zhao Y, Huang T, Jin X, Gong XM, Lu YZ
Appl Immunohistochem Mol Morphol 2023 Jul 1;31(6):354-362. Epub 2023 Jun 5 doi: 10.1097/PAI.0000000000001125. PMID: 37278279Free PMC Article
Aihara T, Kumamaru H, Ishitobi M, Miyashita M, Miyata H, Tamura K, Yoshida M, Ogo E, Nagahashi M, Asaga S, Kojima Y, Kadoya T, Aogi K, Niikura N, Iijima K, Hayashi N, Kubo M, Yamamoto Y, Takeuchi Y, Imoto S, Jinno H
Breast Cancer Res Treat 2022 Dec;196(3):635-645. Epub 2022 Oct 23 doi: 10.1007/s10549-022-06749-3. PMID: 36273358
Lee M, Jara-Lazaro AR, Cheok PY, Thike AA
Singapore Med J 2022 Jul;63(7):394-401. Epub 2021 Apr 16 doi: 10.11622/smedj.2021031. PMID: 33866710Free PMC Article
Nurlaila I, Telisinghe PU, Ramasamy R
Immunol Lett 2013 Nov-Dec;156(1-2):123-6. Epub 2013 Oct 11 doi: 10.1016/j.imlet.2013.10.001. PMID: 24120509
Malyuchik SS, Kiyamova RG
Exp Oncol 2008 Jun;30(2):96-101. PMID: 18566570

Clinical prediction guides

Aihara T, Kumamaru H, Ishitobi M, Miyashita M, Miyata H, Tamura K, Yoshida M, Ogo E, Nagahashi M, Asaga S, Kojima Y, Kadoya T, Aogi K, Niikura N, Iijima K, Hayashi N, Kubo M, Yamamoto Y, Takeuchi Y, Imoto S, Jinno H
Breast Cancer Res Treat 2022 Dec;196(3):635-645. Epub 2022 Oct 23 doi: 10.1007/s10549-022-06749-3. PMID: 36273358
Romero P, Benhamo V, Deniziaut G, Fuhrmann L, Berger F, Manié E, Bhalshankar J, Vacher S, Laurent C, Marangoni E, Gruel N, MacGrogan G, Rouzier R, Delattre O, Popova T, Reyal F, Stern MH, Stoppa-Lyonnet D, Marchiò C, Bièche I, Vincent-Salomon A
Am J Pathol 2018 Oct;188(10):2378-2391. Epub 2018 Aug 1 doi: 10.1016/j.ajpath.2018.06.021. PMID: 30075151
Chu Z, Lin H, Liang X, Huang R, Tang J, Bao Y, Jiang J, Zhan Q, Zhou X
Jpn J Clin Oncol 2015 Jul;45(7):637-41. Epub 2015 Apr 10 doi: 10.1093/jjco/hyv052. PMID: 25862826
Nurlaila I, Telisinghe PU, Ramasamy R
Immunol Lett 2013 Nov-Dec;156(1-2):123-6. Epub 2013 Oct 11 doi: 10.1016/j.imlet.2013.10.001. PMID: 24120509
Rapin V, Contesso G, Mouriesse H, Bertin F, Lacombe MJ, Piekarski JD, Travagli JP, Gadenne C, Friedman S
Cancer 1988 Jun 15;61(12):2503-10. doi: 10.1002/1097-0142(19880615)61:12<2503::aid-cncr2820611219>3.0.co;2-3. PMID: 2835145

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...